Fractal globule model Lieberman-Aiden’s new technique for creating 3-D genomic maps (Hi-C), gave him evidence him to theorize that the structure of the human genome forms a “fractal globule.” Here the genome forms super-dense, knot-free “globules of globules of globules,” which allows for regions in 1-D to also occur nearby in 3-D. Nearby regions are indicated using similar colors.